What Is Globulin?

Globulin is the name for a group of proteins that are soluble in salt solutions. They are made by the liver and the immune system and form a large proportion of blood serum protein.[1]

Which tests include this marker?

What Role Does It Play in The Body?

The globulin part of blood encompasses hundreds of serum proteins including carrier proteins, enzymes, complement and immunoglobulins. Therefore, globulins have an important role in the immune system. Globulins can be split into 5 groups α1, α2, β1,  β2  and γ.

Malnutrition can cause a decrease in total globulins. Increased globulins, on the other hand, can signify dehydration or can be caused by blood or autoimmune diseases.

A total protein test will take into consideration both albumin and globulin levels.

How Does Globulin Affect My Wellbeing?

If you have an increased globulin level, then it is possible that dehydration could cause this. Dehydration can cause symptoms such as:

  • Increased thirst
  • Tiredness
  • Dry mouth, lips and tongue
  • Headaches
  • Dry skin
  • Not needing to pee as often as usual

Dehydration can also influence your mental status, too. This is also true if you are malnourished. In which case, your energy levels will be low, and you may not have the desire to carry out your usual daily activities. If you have decreased levels, then this may be a result of liver disease or malnutrition.  Liver injury or disease such as hepatitis can also affect your general wellbeing. Hepatitis can present itself as flu-like symptoms and generally make you feel unwell. 

How Can I Improve My Result?

Low globulin levels can be an indicator of problems with the liver and kidneys. Therefore, it is important to maintain a healthy and balanced lifestyle.


If your levels are low you should increase your intake of protein. Good sources are beef, pork, lamb, seafood, dairy products and soy. You should also ensure you are getting a good amount of dietary fibre in your diet particularly fruit, vegetables and wholegrains.

You should always make sure you are well hydrated. That doesn’t mean you should only drink water, fluids can include squash, tea, coffee and fruit juice.


There is evidence that there are significant benefits of regular exercise on overall fitness, the cardiovascular system, health-related quality of life and nutritional parameters, particularly in those with kidney disease.[2]

However, exercise has major benefits for our wellbeing too. Exercise can help to reduce the symptoms of depression, self-esteem and anxiety.

We should all aim for around 150 minutes of aerobic exercise per week. Activities may include jogging, walking, swimming, cycling, exercise classes, sports matches or tennis.

Tests that include this marker

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[1] Lab Tests Online UK. (2017). Globulin. Available at:

[2] Heiwe, S and Jacobson, S, H (2011). Exercise Training for Adults with Chronic Kidney Disease (Review). Cochrane Database of Systematic Reviews: 10.

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