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How Does Progesterone Influence Female Fertility

The ovarian hormone that sustains pregnancy is called progesterone and is a key hormone in the regulation of female fertility.

In this blog we take a look at progesterone providing more detail on what progesterone is, and the role it plays in female fertility.

Progesterone And Fertility

The actions of progesterone in the female menstrual cycle are regarded as critical for the control of female reproduction. Progesterone is also vital after conception because it sustains the pregnancy.

There are many aspects of a female’s health and lifestyle which can affect her fertility, including:

    • Ovulation problems
    • Damage to the womb or fallopian tubes
    • Endometriosis
    • Age
    • Weight
    • Smoking
    • Hormones


What Is Progesterone?

Progesterone is a member of the steroid hormone group, progestogens. During the second phase of the menstrual cycle, known as the luteal phase, progesterone is secreted by a structure called the corpus luteum in the ovary.

Ovulation occurs around the 14th day of the menstrual cycle and is when an egg is released from the ovary. An ovarian follicle encapsulates the egg until this point and when it ruptures, releasing the egg, a corpus luteum is formed. The corpus luteum releases progesterone to prepare the body for a potential pregnancy. If the egg is not fertilised, the progesterone levels fall as the corpus luteum breaks down and a new menstrual cycle will begin.

However, if the egg is fertilised and pregnancy occurs, progesterone will continue to be secreted and will increase. Progesterone stimulates the growth of blood vessels to the womb and the release of nutrients from glands in the womb to feed the early developing embryo. At first, the progesterone is still provided by the corpus luteum, until the placenta has developed between weeks 8 and 12 of pregnancy.


Progesterone And Fertility

“Progesterone is a hormone that is produced by the ovaries after ovulation, and the right levels are key to getting pregnant and staying pregnant,” says the general manager of the Harley Street Fertility Clinic, Dr Suvir Venkataraman. It is sometimes referred to as the ‘hormone of pregnancy’.

If your progesterone levels are low or your shown to be deficient, this can affect your ability to conceive. However, progesterone levels rise and fall depending on the stage of the menstrual cycle. Progesterone along with other hormones help to prepare a woman’s body for pregnancy.

Oestrogen, another hormone, stimulates the growth and development of the lining of the womb (endometrium). Meanwhile an increase in luteinising hormone (LH) causes ovulation to occur, so an egg is released from one of the two ovaries. Where the egg was released in the ovary, a small mass of cells forms, known as the corpus luteum. The corpus luteum produces progesterone which prepares the uterus for the potential implantation of a fertilised egg.

Progesterone levels usually peak at around day 21 of the menstrual cycle. Progesterone levels can be tested and if it is shown that they do not rise and fall monthly, then a female may not be having regular menstrual periods or may not be ovulating. Of course, this can make it difficult for a woman to become pregnant, especially if there is no egg being released from the ovaries.

So, in short, progesterone:

  • Prepares the uterus for the implantation of a fertilised egg
  • Thickens the cervical mucus and the inner lining of the vagina to top sperm from getting through
  • A normal menstrual period is actually progesterone-withdrawal bleeding
  • If pregnancy doesn’t occur progesterone levels fall and a new menstrual cycle can begin
  • If pregnancy does occur, the corpus luteum caries on secreting progesterone to sustain pregnancy


Interesting Facts About Progesterone

  • Progesterone levels are naturally higher during multiple pregnancies such as twins or triplets
  • Progesterone has no role in male fertility
  • Progesterone is essential for preparing the female body for pregnancy
  • The fall in progesterone during pregnancy is what stimulates the onset of labour

Because progesterone stimulates the body to prepare for pregnancy, there is some research that suggests progesterone may underlie certain psychological processes which also prepare females for potential pregnancy. Therefore, rising cyclical progesterone levels may promote behaviours in females which makes them create a safe environment for them and their child.


Our home progesterone test will confirm if ovulation has occurred and is taken on day 21 of your menstrual cycle. Lab analysed results within 2 working days of receipt.
1 Biomarkers Included
Lab analysed progesterone test to confirm if ovulation has occurred.


  1. Hart, R, J. (2016). Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics. Physiol Rev: 96, pp 873-909.
  2. Kubota, K et al. (2016). Rethinking Progesterone Regulation of Female Reproductive Cyclicity. PNAS: 113(15), PP 4212-4217.
  3. Reynolds, T, A et al. Progesterone and Women’s Anxiety Across the Menstrual Cycle. Hormones and Behaviour: 102, pp 34-40.


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