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Progesterone is a hormone released by the corpus luteum in the ovary and plays a key part in your menstrual cycle and the early stages of pregnancy. Progesterone belongs to a family of steroid hormones called ‘progestogens’, and is mainly secreted during the second half of your menstrual cycle, called the ‘Luteal Phase’.
Progesterone prepares your body for pregnancy, just in case the egg, which is released around day 14 of your cycle, is fertilised. If the egg isn’t fertilised, progesterone levels fall and a new menstrual cycle will begin.
If the egg is fertilised, progesterone is required to help sustain the pregnancy. Some of the roles progesterone plays in pregnancy include:
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Progesterone levels naturally fluctuate during your menstrual cycle, and will begin to decline as you transition to menopause.
Progesterone levels are low during the first phase of the menstrual cycle, called the ‘follicular phase’, ranging between 0-0.6nmol/L.
During ovulation, levels rise to 0.2-13.2nmol/L. They rise again after ovulation, known as the ‘luteal phase’, to between 13.1-46.3nmol/L.
Postmenopausal levels tend to be below 0.4nmol/L.
A progesterone level of 30nmol/L or above on day 21 of your cycle is indicative of ovulation. You can test your progesterone levels with our easy-to-do, at-home progesterone blood test, or get even more insight with other key hormones involved in the menstrual cycle with our advanced female hormone mapping test, MyFORM®.
Progesterone levels naturally rise during your menstrual cycle and remain elevated when pregnant. However, high progesterone can also be the result of ovarian cysts, problems with your adrenal glands (such as congenital adrenal hyperplasia) and ovarian cancer. Symptoms of high progesterone are linked to premenstrual syndrome or PMS symptoms, and include;
Progesterone levels decline naturally at the end of your menstrual cycle, into the luteal phase. But consistently low progesterone levels across your entire menstrual cycle can cause a variety of symptoms that include:
If you have low progesterone when pregnant, you may experience:
If you’re concerned you may be suffering from high or low progesterone, a home progesterone test can help you get the help you need. You’ll get your results within 2 working days of your sample reaching our lab, making it a quick and easy way to keep track of your health.
Low progesterone levels can be caused by a variety of things, including:
If you’re experiencing symptoms associated with low progesterone, a blood test is the best way to get diagnosed. Our ground-breaking female hormone mapping test, MyFORM, can show you how your progesterone levels are rising and falling across your entire menstrual cycle – alongside oestrogen, follicle-stimulating hormone and luteinising hormone. This will help identify if you’re suffering from low or high progesterone levels, and if you’ve had an anovulatory cycle.
If your blood test results show progesterone levels outside of the normal range for your age, you should discuss next steps with your GP. They will carry out further investigations to understand the underlying cause and the best treatment.
For women who have low progesterone due to perimenopause/menopause, HRT may be prescribed. Although HRT is prescribed to relieve the symptoms associated with declining oestrogen levels, treatment does include progesterone, this is known as combined HRT.
There are pros and cons of taking HRT, which need to be considered on an individual basis.
Eating a healthy and balanced is important for maintaining healthy hormones. Key nutrients that can help support your levels of progesterone include vitamin B, C and zinc. However, causes of low or high progesterone should be investigated by your healthcare provider before any changes are made to your diet.
Exercise can help to improve the pain and discomfort experienced during your menstrual cycle.[1]
Exercise is also beneficial for mood changes too. Physical activity can release endorphins which can increase your mood. During your period you go through hormonal changes which can affect the way you feel. By participating in exercise, it is possible to overcome these feelings and improve your social life.
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Thom works in NHS general practice and has a decade of experience working in both male and female elite sport. He has a background in exercise physiology and has published research into fatigue biomarkers.
Dr Thom Phillips
Head of Clinical Services
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