Free Testosterone (calculated)

What Is Testosterone?

Testosterone is a steroid hormone which is predominantly made in the male testes. The hormone is stimulated and controlled by luteinising hormone which is produced by the pituitary gland in the brain. Women also produce a small amount of testosterone in their ovaries and adrenal glands.[1]

Free testosterone is the amount of testosterone which is not bound to either sex hormone binding globulin or albumin. Instead, it is freely travelling around the body in the blood without being bound to another protein.

Which tests include this marker?

What Role/s Does It Play in The Body?

Testosterone has an important role in the human body affecting the brain, bone and muscle mass, fat distribution, the heart and blood vessels, energy levels and sexual function. 

The secretion of testosterone follows a circadian rhythm in men i.e. the highest levels are witnessed in the early hours of the morning. As men age, their testosterone levels decrease which can result in a reduced libido, lower bone density, reduced muscle mass and delayed cognitive function. The levels of testosterone in men are as follows:

  • 2% free testosterone
  • 38% bound to albumin
  • 60% bound to sex hormone binding globulin (SHBG)[2]

In early adulthood, testosterone is essential for growth and the regulation of the prostate gland. Testosterone is carried to the prostate gland via the blood where it is then converted to dihydrotestosterone which encourages prostatic cell growth.[3]

Measuring free testosterone is more difficult than measuring total testosterone. As free testosterone is unbound to any other protein is also referred to as bioavailable testosterone because it is easily available for use by the body. The calculation of total testosterone is not a reliable index of free testosterone.[4]

How Does Testosterone Affect My Wellbeing?

High levels of testosterone in women can cause Polycystic Ovary Syndrome (PCOS).  The condition affects how the ovaries work and can cause unwanted side effects. Symptoms of PCOS include:

  • Irregular or the absence of periods
  • Excess hair growth (known as hirsutism) usually affects the face, chest, back or buttocks
  • Acne
  • Weight gain
  • Hair loss
  • Difficulty getting pregnant
  • Increased risk of high cholesterol and type 2 diabetes[5]

PCOS affects 1 in 5 women who are of reproductive age and can have some psychological side effects, like:

  • Reduced quality of life
  • Low self-esteem
  • Depression
  • Anxiety

The condition is chronic and usually first manifests in a women’s teenage years. The condition can also result in infertility which can also lead to psychological symptoms.[6]

Individuals who have a naturally higher level of testosterone are more motivated to take part in exercise and train. Higher levels of testosterone are more beneficial in sports which require strength and power.

Low levels of testosterone in men are associated with an increased risk of diabetes, cardiovascular disease, osteoporosis and a reduced libido.[7] 

How Can I Improve My Result?

Testosterone is an important hormone with regards to exercise and exercise training. This is largely due to the fact it is has a major role in growth and maintenance of muscle and bone. Studies have shown that the more intense the exercise, the higher the levels of testosterone in the body.[8]


Diet

Eating the right diet can help to control some of the symptoms and risks associated with PCOS. Heart disease and diabetes are side effects of PCOS and so you should incorporate an increased amount of fruit and vegetables into your diet, eat lean meat rather than fatty versions and limit the amount of sugary and fatty foods you eat. Making small changes such as swapping full-fat dairy for low-fat equivalents can help to make a difference.

Eat a diet which has a low glycaemic index may also be beneficial. Low GI diets incorporate foods which cause your blood sugar to rise slowly can reduce the symptoms of PCOS. Foods include:

  • Oatmeal
  • Oat Bran
  • Muesli
  • Pasta
  • Barley
  • Bulgar wheat
  • Sweet potato
  • Butter beans
  • Peas
  • Legumes
  • Lentils
  • Fruits
  • Carrots
  • Non-starchy vegetables
  • 100% stone-ground whole wheat bread

Low GI diets and foods may help to alleviate the symptoms of PCOS because many women who have the condition are resistant to insulin. Insulin is a hormone which helps the body to use the energy from food.[9]

Low testosterone levels have been associated with low protein intake. Insulin is associated with SHBG levels. Protein intake has been shown to increase insulin levels and insulin has been shown to decrease SHBG levels which in turn can increase the amount of testosterone.[10] 

Exercise

As men age, serum testosterone levels decrease, particularly between the ages of 40 and 50. Men who are in their 70s have around a 40% lower testosterone level than men in their 20s. The age-related decline in testosterone is associated with a lower quality of life, a decrease in muscle mass and osteoporosis. Studies in middle-aged men show that moderate to vigorous exercise can see greater improvements in testosterone levels and in turn improves cardiopulmonary fitness.[11]

Being overweight can increase the severity of the symptoms associated with PCOS in women. Physical activity can help with weight loss but perhaps, more importantly, it can improve the body’s response to insulin.7

Weight loss in PCOS patients is also beneficial for all other symptoms of the condition.[12] Exercise should be encouraged and a plan should be devised with your GP.

Further studies in women have shown that individuals who have a higher free testosterone level have a significant competitive advantage over their rivals. Testosterone is a performance-enhancing androgen and can have beneficial effects on muscle and body mass as well as red blood cell development.[13]

Tests that include this marker

Male Hormones

A comprehensive test of key male hormones which can affect libido, muscle strength, energy and much more.

£79

References

[1] Lab Tests Online UK. (2016). Testosterone Test. Available at: https://labtestsonline.org.uk/tests/testosterone-test

[2] Tyagi, V., Scordo, M., Yoon, R, S., Liporace, F, A and Wissner Greene, L. (2017). Revisiting the Role of Testosterone: Are We Missing Something? Rev Urol: 19(1), pp 16-24.

[3] Alvarado, L, C. (2011). Total Testosterone in Young Men is More Closely Associated than Free Testosteron with Prostate Cancer Disparities. Ther Adv Urol: 3(3), pp 99-106.

[4] Mueller, A., Dittrich, R., Cupisti, S., Beckmann, M, W and Binder, H. (2006). Is It Necessary to Measure Free Testosterone to Assess Hyperandrogenemia in Women? The Role of Calculated Free and Bioavailable Testosterone. Exp Clin Endocrinol Diabetes: 114(4), pp 182-187.

[5] Ehrmann, D, A. (2005). Polycystic Ovary Syndrome. The New England Journal of Medicine: 352, pp 1223-36.

[6] Teede, H., Deeks, A and Moran, L. (2010). Polycystic Ovary Syndrome: A Complex Condtion with Psychological, Reproductive and Metabolic Manifestations that Impacts on Health Across the Lifespan. BMC Medicine: 8.

[7] Shores, M, M., Smith, N, L., Forsberg, C, W., Anawalt, B, D and Matsumoto, A, M. (2012). Testosterone Treatment and Mortality in Men with Low Testosterone Levels. J Clin Endocrinol Metab: 97(6), pp 2050-2058.

[8] Lane, A, R and Hackney, A, C. (2014). Relationship Between Salivary and Serum Testosterone Levels in Response to Different Exercise Intensities. Hormones.

[9] The Association of UK Dietitians. (2016). Polycystic Ovary Syndrome (PCOS). Available at: https://www.bda.uk.com/foodfacts/pcos.pdf

[10]Longcope, C., Feldman, J, B., McKinlay, B and Araujo, A, B. (2000). Diet and Sex Hormone-Binding Globulin. The Journal of Clinical Endocrinology and Metabolism: 85(1), pp 293-296.

[11] Hawkin, V, H., Foster-Schubert, K and Chubak, J et al. (2008). Effect of Exercise of Serum Sex Hormones in Men: A 12 Month Randomized Clinical Trial. Med Sci Sports Exerc: 40(2), pp 223-233.

[12] Khademi, A., Alleyassin, A., Aghahisseini, M., Tabataeefar, L and Amini, M. (2010). The Effect of Exercise in PCOS Women Who Exercise Regularly. Asian Journal of Sports Medicine: 1(1), pp 35-40.

[13] Bermon, A and Garnier, P, Y. (2017). Serum Androgen Levels and Their Relation to Performance in Track and Field: Mass Spectrometry Results from 2127 Observations in Male and Female Elite Athletes. Br J Sports Med:0, pp 1-7.


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